Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA

Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA

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Summary: Oriens lacunosum-moleculare (O-LM) interneurons constitute 40% of hippocampal Cubicles interneurons expressing Somatostatin (SST).Recent evidence has indicated a dual origin for these cells in the medial and caudal ganglionic eminences (MGE and CGE), with expression of Htr3a as a distinguishing factor.This is strikingly different from cortical SST interneurons that have a single origin within the MGE/preoptic area (POA).We reassessed the origin of hippocampal SST interneurons using a range of genetic lineage-tracing mice combined with single-cell transcriptomic analysis.We find a common origin for all hippocampal SST interneurons in NKX2-1-expressing progenitors Meeting Table of the telencephalic neuroepithelium and an MGE/POA-like transcriptomic signature for all SST clusters.

This suggests that functional heterogeneity within the SST CA1 population cannot be attributed to a differential MGE/CGE genetic origin.: In this article, Kessaris and colleagues combine genetic lineage tracing and single-cell transcriptomic analysis to identify the embryonic origin of hippocampal CA1 Somatostatin interneurons.They report a common origin in the medial ganglionic eminence/preoptic area from neuroepithelial precursors expressing NKX2-1.Keywords: Somatostatin, hippocampus, O-LM, fate-mapping, embryonic origin, single-cell sequencing, interneurons.